Cardiac diastolic dysfunction in high-fat diet fed mice is associated with lipotoxicity without impairment of cardiac energetics in vivo.

@article{Abdurrachim2014CardiacDD,
  title={Cardiac diastolic dysfunction in high-fat diet fed mice is associated with lipotoxicity without impairment of cardiac energetics in vivo.},
  author={Desiree Abdurrachim and Jolita {\vC}iapaitė and Bart Wessels and Miranda Nabben and Joost J.F.P. Luiken and Klaas Nicolay and Jeanine J Prompers},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1842 10},
  pages={
          1525-37
        }
}
  • Desiree Abdurrachim, Jolita Čiapaitė, +4 authors Jeanine J Prompers
  • Published in Biochimica et biophysica acta 2014
  • Biology, Medicine
  • Obesity is often associated with abnormalities in cardiac morphology and function. This study tested the hypothesis that obesity-related cardiomyopathy is caused by impaired cardiac energetics. In a mouse model of high-fat diet (HFD)-induced obesity, we applied in vivo cardiac (31)P magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) to investigate cardiac energy status and function, respectively. The measurements were complemented by ex vivo determination of oxygen… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 28 CITATIONS

    Protocols and Methodologies in Basic Science and Clinical Cardiac MRI

    VIEW 5 EXCERPTS
    CITES BACKGROUND & METHODS
    HIGHLY INFLUENCED

    Metabolic Profiling of the Diabetic Heart: Toward a Richer Picture

    VIEW 4 EXCERPTS
    CITES METHODS, BACKGROUND & RESULTS
    HIGHLY INFLUENCED

    Obesity-induced changes in kidney mitochondria and endoplasmic reticulum in the presence or absence of leptin.

    VIEW 12 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Cardiac function and intracellular Ca2+ handling proteins are not impaired by high-saturated-fat diet-induced obesity

    • A F Deus, D F Vileigas, +5 authors A C Cicogna
    • Biology, Medicine
    • Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
    • 2019