Cardiac contractile reserve in spontaneously hypertensive rats.

1. In response to graded infusions of isoprenaline, adult spontaneously hypertensive rats (20-24 weeks old) showed diminished responses of left ventricular contractile indices, diminished chronotropic responses and impairment of left ventricular relaxation rate as compared with matched Kyoto-Wistar rats. 2. These findings suggest reduced capacity to… CONTINUE READING