Cardiac commitment of primate embryonic stem cells

  title={Cardiac commitment of primate embryonic stem cells},
  author={Julia Leschik and Sonia Stefanovic and Benjamin Brinon and Michel Puc{\'e}at},
  journal={Nature Protocols},
Primate nonhuman and human embryonic stem (ES) cells provide a powerful model of early cardiogenesis. Furthermore, engineering of cardiac progenitors or cardiomyocytes from ES cells offers a tool for drug screening in toxicology or to search for molecules to improve and scale up the process of cardiac differentiation using high-throughput screening technology, as well as a source of cell therapy of heart failure. Spontaneous differentiation of ES cells into cardiomyocytes is, however, limited… CONTINUE READING


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