Cardiac cholinergic NO-cGMP signaling following acute myocardial infarction and nNOS gene transfer.

@article{Dawson2008CardiacCN,
  title={Cardiac cholinergic NO-cGMP signaling following acute myocardial infarction and nNOS gene transfer.},
  author={Tom A. Dawson and Dayuan Li and Thad Woodward and Zoe Barber and Luchen Wang and David J. Paterson},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={295 3},
  pages={H990-H998}
}
Myocardial infarction (MI) is associated with oxidative stress, which may cause cardiac autonomic impairment. We tested the hypothesis that acute MI disrupts cardiac cholinergic signaling by impairing nitric oxide (NO)-cGMP modulation of acetylcholine (ACh) release and whether the restoration of this pathway following cardiac neuronal NO synthase (nNOS) gene transfer had any bearing on the neural phenotype. Guinea pigs underwent four ligature coronary artery surgery (n = 50) under general… CONTINUE READING