Cardiac channelopathies: from men to mice.

@article{Charpentier2004CardiacCF,
  title={Cardiac channelopathies: from men to mice.},
  author={F. Charpentier and Sophie Demolombe and Denis Escande},
  journal={Annals of medicine},
  year={2004},
  volume={36 Suppl 1},
  pages={28-34}
}
During recent years, genetic manipulations in the mouse aimed to settle animal models of cardiac channelopathies. Among this group of diseases, the genetically heterogeneous long-QT (LQT) syndrome has instigated several models. Models of the LQT1 syndrome have been obtained by invalidation of Kcnq1 encoding a voltage-dependent K+ channel alpha-subunit, LQT2 syndrome by invalidation of Merg also encoding a voltage-dependent K+ channel alpha-subunit, LQT3 by knocking-in a gain-of-function… CONTINUE READING

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