Cardiac cell-cell junctions in health and disease: Electrical versus mechanical coupling.

@article{Noorman2009CardiacCJ,
  title={Cardiac cell-cell junctions in health and disease: Electrical versus mechanical coupling.},
  author={M. Mohamad Noorman and Marcel A G van der Heyden and Toon A. B. van Veen and Moniek G.P.J. Cox and Richard N. W. Hauer and Jacques Mt de Bakker and Harold V. M. van Rijen},
  journal={Journal of molecular and cellular cardiology},
  year={2009},
  volume={47 1},
  pages={
          23-31
        }
}
Intercalated discs are the membrane sites where individual cardiomyocytes are connected to each other. Adherens-, desmosomal-, and gap junctions are situated in the intercalated disc and ensure mechanical coupling between cells and enable propagation of electrical impulses throughout the heart. A number of cardiac disorders, for example arrhythmogenic right ventricular dysplasia/cardiomyopathy, have been described in which an impaired mechanical coupling leads to electrical dysfunction, with… CONTINUE READING

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