Cardiac calsequestrin: quest inside the SR.

  title={Cardiac calsequestrin: quest inside the SR.},
  author={S{\'a}ndor Gy{\"o}rke and Sarah C. W. Stevens and Dmitry Terentyev},
  journal={The Journal of physiology},
  volume={587 Pt 13},
Although calsequestrin (CASQ), a major sarcoplasmic reticulum (SR) Ca2+ binding protein, was discovered more than 30 years ago, its precise roles and modes of operation in both skeletal and cardiac muscle remain to be elucidated (Rios, 2009, this issue; Knollmann, 2009, this issue). Recent years witnessed a significant surge of interest in this Ca2+ binding protein after mutations in the gene encoding the cardiac isoform of calsequestrin (CASQ2) were linked to exercise-induced cardiac death due… CONTINUE READING


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Ca-dependency of cardiac SR Ca release reveals no sign of Ca-dependent inactivation and points to luminal Ca as a principal regulator of release

  • SC Stevens, D Terentyev, S Györke
  • 2009
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