Cardiac beta-adrenoceptor modulation by amiodarone.

  title={Cardiac beta-adrenoceptor modulation by amiodarone.},
  author={P. Nokin and M. Clinet and Peter Sch{\"o}nfeld},
  journal={Biochemical pharmacology},
  volume={32 17},
beta-Antiadrenergic properties are part of the pharmacological characteristics of amiodarone. In the present study, the action of amiodarone on rat-heart beta-adrenoceptors was investigated. [125I]Cyanopindolol (CYP) was used to label beta-adrenoceptors in crude rat-heart microsomes. In competition binding experiments, amiodarone up to 10(-6) M did not… CONTINUE READING