Cardiac autophagy is a maladaptive response to hemodynamic stress.

  title={Cardiac autophagy is a maladaptive response to hemodynamic stress.},
  author={Hongxin Zhu and Paul Tannous and Janet L. Johnstone and Y Megan Kong and John M Shelton and J. A. Richardson and Vien Le and Beth Levine and Beverly A. Rothermel and Joseph A Hill},
  journal={The Journal of clinical investigation},
  volume={117 7},
Cardiac hypertrophy is a major predictor of heart failure and a prevalent disorder with high mortality. Little is known, however, regarding mechanisms governing the transition from stable cardiac hypertrophy to decompensated heart failure. Here, we tested the role of autophagy, a conserved pathway mediating bulk degradation of long-lived proteins and cellular organelles that can lead to cell death. To quantify autophagic activity, we engineered a line of "autophagy reporter" mice and confirmed… CONTINUE READING
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