Cardiac autonomic dysfunction is associated with white matter lesions in patients with mild cognitive impairment.

@article{Galluzzi2009CardiacAD,
  title={Cardiac autonomic dysfunction is associated with white matter lesions in patients with mild cognitive impairment.},
  author={Samantha Galluzzi and Franco Nicosia and Cristina Geroldi and Alberto Alicandri and Matteo Bonetti and Giuseppe Romanelli and Roberto Zulli and Giovanni B. Frisoni},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2009},
  volume={64 12},
  pages={1312-5}
}
BACKGROUND Cardiac autonomic dysfunction has been associated with cognitive impairment, but the underlying pathogenesis is complex and cerebral white matter lesions (WMLs) might be implicated. METHODS Time and frequency heart rate variability (HRV) and visual rating of WMLs were carried out in 42 patients with mild cognitive impairment. RESULTS After adjustment for relevant demographic and clinical characteristics, including left ventricular mass, reduced HRV indices of parasympathetic… CONTINUE READING