Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization.

  title={Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization.},
  author={D. Brown and M. Aon and C. Frasier and Ruben C. Sloan and A. Maloney and E. Anderson and B. O’Rourke},
  journal={Journal of molecular and cellular cardiology},
  volume={48 4},
  • D. Brown, M. Aon, +4 authors B. O’Rourke
  • Published 2010
  • Medicine, Biology
  • Journal of molecular and cellular cardiology
  • We have previously proposed that the heterogeneous collapse of mitochondrial inner membrane potential (DeltaPsi(m)) during ischemia and reperfusion contributes to arrhythmogenesis through the formation of metabolic sinks in the myocardium, wherein clusters of myocytes with uncoupled mitochondria and high K(ATP) current levels alter electrical propagation to promote reentry. Single myocyte studies have also shown that cell-wide DeltaPsi(m) depolarization, through a reactive oxygen species (ROS… CONTINUE READING
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