Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization.

@article{Brown2010CardiacAI,
  title={Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization.},
  author={David Brown and Miguel Antonio Aon and Chad R. Frasier and Ruben Carnell Sloan and Andrew H Maloney and Ethan J. Anderson and Brian O'Rourke},
  journal={Journal of molecular and cellular cardiology},
  year={2010},
  volume={48 4},
  pages={673-9}
}
We have previously proposed that the heterogeneous collapse of mitochondrial inner membrane potential (DeltaPsi(m)) during ischemia and reperfusion contributes to arrhythmogenesis through the formation of metabolic sinks in the myocardium, wherein clusters of myocytes with uncoupled mitochondria and high K(ATP) current levels alter electrical propagation to promote reentry. Single myocyte studies have also shown that cell-wide DeltaPsi(m) depolarization, through a reactive oxygen species (ROS… CONTINUE READING
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