Cardiac apoptosis in burned rats with delayed fluid resuscitation.

  title={Cardiac apoptosis in burned rats with delayed fluid resuscitation.},
  author={Guiying Wang and Zhaofan Xia and Byung Jo Yu and Shichu Xiao and Yulong L. Chen},
  journal={Burns : journal of the International Society for Burn Injuries},
  volume={27 3},
Clinical and experimental studies have shown that delayed fluid resuscitation postburn decreases heart function. We hypothesized that apoptosis occurs in the cardiomyocyte in this condition. To investigate this hypothesis, rats were burned, fluid resuscitation was delayed, and the integrity of cardiac genomic DNA in the burned rats was determined with an LM-PCR Ladder Assay kit. DNA fragmentation shown as DNA ladders on gels, the hallmark of apoptosis, was found in the heart tissue of these… CONTINUE READING

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