Cardiac angiotensin converting enzyme and myocardial fibrosis in the rat.

  title={Cardiac angiotensin converting enzyme and myocardial fibrosis in the rat.},
  author={Ya-ping Sun and Jack P. M. Cleutjens and Alberto A. Diaz-Arias and Karl T. Weber},
  journal={Cardiovascular research},
  volume={28 9},
OBJECTIVE The aim was to test the hypothesis that cardiac angiotensin converting enzyme (ACE) is related to the accumulation of fibrous tissue in the heart. METHODS A model of tissue repair (pericardiotomy with left coronary artery ligation) was used, together with the following: quantitative in vitro autoradiography (125I-351A) to determine ACE binding density; immunohistochemistry (monoclonal ACE antibody, 9B9) to identify cells expressing ACE; and in situ hybridisation to localise cells… CONTINUE READING
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