Cardiac and vascular phenotypes in the apolipoprotein E-deficient mouse

@inproceedings{Vasquez2011CardiacAV,
  title={Cardiac and vascular phenotypes in the apolipoprotein E-deficient mouse},
  author={Elisardo Corral Vasquez and Ver{\^o}nica A. Peotta and Agata Lages Gava and Thiago M. C. Pereira and Silvana dos Santos Meyrelles},
  booktitle={Journal of Biomedical Science},
  year={2011}
}
Cardiovascular death is frequently associated with atherosclerosis, a chronic multifactorial disease and a leading cause of death worldwide. Genetically engineered mouse models have proven useful for the study of the mechanisms underlying cardiovascular diseases. The apolipoprotein E-deficient mouse has been the most widely used animal model of atherosclerosis because it rapidly develops severe hypercholesterolemia and spontaneous atherosclerotic lesions similar to those observed in humans. In… CONTINUE READING