Cardiac and vascular changes in cirrhosis: pathogenic mechanisms.

  title={Cardiac and vascular changes in cirrhosis: pathogenic mechanisms.},
  author={Hongqun Liu and Seyed Ali Gaskari and Samuel Sangkon Lee},
  journal={World journal of gastroenterology},
  volume={12 6},
Cardiovascular abnormalities accompany both portal hypertension and cirrhosis. These consist of hyperdynamic circulation, defined as reduced mean arterial pressure and systemic vascular resistance, and increased cardiac output. Despite the baseline increased cardiac output, ventricular inotropic and chronotropic responses to stimuli are blunted, a condition known as cirrhotic cardiomyopathy. Both conditions may play an initiating or aggravating pathogenic role in many of the complications of… CONTINUE READING
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