Cardiac and skeletal muscle mitochondria have a monocarboxylate transporter MCT1.

@article{Brooks1999CardiacAS,
  title={Cardiac and skeletal muscle mitochondria have a monocarboxylate transporter MCT1.},
  author={George A. Brooks and M A Brown and Charles E Butz and J P Sicurello and Herv{\'e} Dubouchaud},
  journal={Journal of applied physiology},
  year={1999},
  volume={87 5},
  pages={1713-8}
}
To evaluate the potential role of monocarboxylate transporter-1 (MCT1) in tissue lactate oxidation, isolated rat subsarcolemmal and interfibrillar cardiac and skeletal muscle mitochondria were probed with an antibody to MCT1. Western blots indicated presence of MCT1 in sarcolemmal membranes and in subsarcolemmal and interfibrillar mitochondria. Minimal cross-contamination of mitochondria by cell membrane fragments was verified by probing for the sarcolemmal protein GLUT-1. In agreement… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Lactate metabolism in exercising human skeletal muscle: evidence for lactate extraction during net lactate release

  • W. C. Stanley, E. W. Gertz, J. A. Wisneski, D. L. Morris, R. Neese, G. A. Brooks
  • J. Appl. Physiol
  • 1986
Highly Influential
4 Excerpts

Halestrap . Cloning and sequencing of four new mammalian monocarboxylate transporter ( MCT ) homologues confirms the existence of a transporter family with an ancient past

  • N. T. Price, V. N. Jackson, P. A.
  • Biochem . J .
  • 1998

Similar Papers

Loading similar papers…