Cardiac and renal complications of carfilzomib in patients with multiple myeloma.

  title={Cardiac and renal complications of carfilzomib in patients with multiple myeloma.},
  author={Meletios Athanasios Dimopoulos and Maria Roussou and Maria Gavriatopoulou and Erasmia Psimenou and Dimitrios C. Ziogas and Evangelos Eleutherakis-Papaiakovou and Despina Fotiou and Magdalini Migkou and Nikolaos Kanellias and Ioannis Panagiotidis and Argyrios S Ntalianis and Elektra S Papadopoulou and Kimon Stamatelopoulos and Efstathios Manios and Constantinos Pamboukas and S Kontogiannis and Evangelos Terpos and Efstathios Kastritis},
  journal={Blood advances},
  volume={1 7},
Clinical trials with carfilzomib have indicated a low but reproducible incidence of cardiovascular and renal toxicities. Among 60 consecutive myeloma patients treated with carfilzomib-based regimens who were thoroughly evaluated for cardiovascular risk factors, 12% (95% confidence interval, 3.8%-20%) experienced a reversible reduction of left ventricular ejection fraction (LVEF) by ≥20%, an objective measure of cardiac dysfunction. The incidence of LVEF reduction was 5% at 3 months, 8% at 6… CONTINUE READING
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