Cardiac and aortic arch anomalies in the offspring of vitamin A deficient rats correlated with similar human anomalies.

  title={Cardiac and aortic arch anomalies in the offspring of vitamin A deficient rats correlated with similar human anomalies.},
  author={J. Gordon Wilson and Josef Warkany},
  volume={5 4},
Fetal and newborn rats from mothers fed vitamin A deficient diets prior to and during pregnancy exhibited some degree of malformation in 75% of the cases. Twenty-eight of 64 severely abnormal young studied after serial sectioning showed congenital cardiovascular malformations. These consisted of defects in the interventricular septum and in the aortico-pulmonary septum; and of various aortic arch anomalies, such as retroesophageal subclavian artery, right aortic arch, double aortic arch… 

Reduced maternal vitamin A status increases the incidence of normal aortic arch variants

The study suggested that mild alterations in retinoic acid signaling combined with reduced gene dosage of Hectd1, results in a benign aortic arch variant where the transverse aorti arch is shortened between the brachiocephalic and left common carotid arteries.

Embryogenesis of transposition of the great arteries: a lesson from the heart.

  • M. Kirby
  • Medicine
    Circulation research
  • 2002
Historically, knowledge of the embryogenesis of any heart defects has been difficult to attain because of the lack of models in which the pathogenesis of the defect could be studied prospectively.

Aortic arch anomalies associated with the administration of epinephrine in chick embryos.

Single doses of epinephrine administered to 83 groups of chick embryos at 2-h intervals, produced a spectrum of aortic arch anomalies; those involving the right 4th arch (arcus aortae) were consistently associated with ventricular septal defects.

Abnormal development of the sinuatrial venous valve and posterior hindbrain may contribute to late fetal resorption of vitamin A-deficient rat embryos.

An essential role for retinoid signaling between the late gastrula and early somite stages in the rat embryo for normal morphogenesis of the primitive heart tube and the posterior hindbrain is supported.

Genetic and environmental influences on malformations of the cardiac outflow tract

Work in this field is at a new cusp, with the ability to measure xenobiotics exposure, document xenobiotic metabolizing genetic polymorphisms and integrate these data into models of cardiac teratogenesis.

Congenital diaphragmatic hernia and associated cardiovascular malformations: Type, frequency, and impact on management

An extensive review of the literature and obtained new data indicates that atrial and ventricular septal defects, conotruncal defects, and left ventricular outflow tract obstructive defects were the most common type of CVMs, but proportional to the frequency of occurrence in the general population.

Extrinsic factors in the genesis of congenital heart disease.

The most common congenital cardiopathies are interpreted by combining this hypothesis with others previously proposed by one of us la Cruz and da Rocha, de la Cruz al., on truncoconal malformations, and ventricular and atrial septal defects.