Cardiac alternans in embryonic mouse ventricles.

@article{Diego2008CardiacAI,
  title={Cardiac alternans in embryonic mouse ventricles.},
  author={Carlos de Diego and Fuhua Chen and Lai-hua Xie and Amish S. Dave and Mya Mya Thu and Christine Rongey and James N. Weiss and Miguel Valderr{\'a}bano},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={294 1},
  pages={H433-40}
}
T-wave alternans, an important arrhythmogenic factor, has recently been described in human fetuses. Here we sought to determine whether alternans can be induced in the embryonic mouse hearts, despite its underdeveloped sarcoplasmic reticulum (SR) and, if so, to analyze the response to pharmacological and autonomic interventions. Immunohistochemistry confirmed minimal sarcoplasmic-endoplasmic reticulum Ca-ATPase 2a expression in embryonic mouse hearts at embryonic day (E) 10.5 to E12.5, compared… CONTINUE READING
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