Cardiac alpha 1-adrenoceptor densities in different mammalian species.

  title={Cardiac alpha 1-adrenoceptor densities in different mammalian species.},
  author={Markus Steinfath and Ying Ying Chen and J. Lavicky and Olaf M Magnussen and Monika Nose and S Rosswag and W. Schmitz and Hasso Scholz},
  journal={British journal of pharmacology},
  volume={107 1},
1. alpha 1-Adrenoceptor densities were studied in cardiac membrane preparations from several mammalian species including human failing hearts under identical experiment conditions; the alpha 1-adrenoceptor antagonist, [3H]-prazosin, was used as radioligand. End-stage heart failure (NYHA IV) in human hearts was due to idiopathic dilated cardiomyopathy. 2. The ventricular alpha 1-adrenoceptor densities were not significantly different in guinea-pig, mouse, pig, calf, and man (11 to 18 fmol mg-1… CONTINUE READING

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