Cardiac aldosterone overexpression prevents harmful effects of diabetes in the mouse heart by preserving capillary density.

@article{Messaoudi2009CardiacAO,
  title={Cardiac aldosterone overexpression prevents harmful effects of diabetes in the mouse heart by preserving capillary density.},
  author={Smail Messaoudi and Paul Ursmar Milliez and Jane-Lise Samuel and Claude Delcayre},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2009},
  volume={23 7},
  pages={2176-85}
}
Recent reports showed an unexpected worsening of endothelial function by aldosterone antagonism in diabetic patients, suggesting that aldosterone could interfere with the detrimental consequences of diabetes on microvasculature and thus on cardiac function. To test this hypothesis, diabetes (D) was induced using streptozotocin in transgenic (Tg) male mice overexpressing aldosterone-synthase in the heart and in wild-type (Wt) mice. Eight weeks after streptozotocin injection, impairment of left… CONTINUE READING

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