Cardiac actin is the major actin gene product in skeletal muscle cell differentiation in vitro.

@article{Bains1984CardiacAI,
  title={Cardiac actin is the major actin gene product in skeletal muscle cell differentiation in vitro.},
  author={W. Bains and Phyllis Ponte and Helen M. Blau and Larry Kedes},
  journal={Molecular and cellular biology},
  year={1984},
  volume={4 8},
  pages={
          1449-53
        }
}
We examined the expression of alpha-skeletal, alpha-cardiac, and beta- and gamma-cytoskeletal actin genes in a mouse skeletal muscle cell line (C2C12) during differentiation in vitro. Using isotype-specific cDNA probes, we showed that the alpha-skeletal actin mRNA pool reached only 15% of the level reached in adult skeletal muscle and required several days to attain this peak, which was then stably maintained. However, these cells accumulated a pool of alpha-cardiac actin six times higher than… CONTINUE READING

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