Cardiac-Specific Overexpression of miR-222 Induces Heart Failure and Inhibits Autophagy in Mice.

@article{Su2016CardiacSpecificOO,
  title={Cardiac-Specific Overexpression of miR-222 Induces Heart Failure and Inhibits Autophagy in Mice.},
  author={Ming Su and Zhiguo Chen and Changxin Wang and Lei Song and Yubao Zou and Lianfeng Zhang and Rutai Hui and Jizheng Wang},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2016},
  volume={39 4},
  pages={1503-11}
}
BACKGROUND MicroRNAs play a crucial role in the regulation of pathological cardiac remodeling and heart failure. Previously, we found that overexpression of miR-221 induces heart failure in mice. The miR-222 and miR-221 share the same gene cluster, however, the role of miR-222 in the regulation of cardiac function remained ill-defined. METHODS AND RESULTS Transgenic mice with cardiac-specific expression of miR-222 (Tg-miR-222) mice were generated. The Tg-miR-222 mice developed significantly… CONTINUE READING
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