Cardiac Specific Knockout of p53 Decreases ER Stress-Induced Mitochondrial Damage

@inproceedings{Chen2019CardiacSK,
  title={Cardiac Specific Knockout of p53 Decreases ER Stress-Induced Mitochondrial Damage},
  author={Qun Chen and Jeremy Thompson and Ying Hu and Anindita Das and Edward Joseph Lesnefsky},
  booktitle={Front. Cardiovasc. Med.},
  year={2019}
}
Endoplasmic reticulum (ER) stress contributes to cardiovascular disease including heart failure. Interactions between the ER and mitochondria during ER stress can impair the mitochondrial respiratory chain and increase cell injury. p53 is a tumor suppressor protein that regulates apoptosis. p53 contributes to the regulation of mitochondrial and ER interactions, especially during the progression of ER stress. The knockout (KO) of p53 leads to decreased injury in hearts following ischemia… CONTINUE READING
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