Cardiac Sarcoidosis: A Review of Contemporary Challenges in Diagnosis and Treatment

@article{Yatsynovich2018CardiacSA,
  title={Cardiac Sarcoidosis: A Review of Contemporary Challenges in Diagnosis and Treatment},
  author={Y. Yatsynovich and N. Dittoe and M. Petrov and N. Maroz},
  journal={The American Journal of the Medical Sciences},
  year={2018},
  volume={355},
  pages={113–125}
}
ABSTRACT Sarcoidosis is a systemic disease characterized by noncaseating granulomas and is often a diagnosis of exclusion. The actual prevalence of cardiac sarcoidosis (CS) is unknown, as studies have demonstrated mixed data. CS may be asymptomatic and is likely more frequently encountered than previously thought. Sudden death may often be the presenting feature of CS. Most deaths attributed to CS are caused by arrhythmias or conduction system disease, and congestive heart failure may occur… Expand
Cardiac sarcoidosis: Case presentation and Review of the literature
TLDR
The case of a patient who presented with cardiac symptoms, whose initial examination was unrevealing, was described and diagnosis was made retrospectively based on later systemic manifestations that revealed characteristic sarcoidosis findings. Expand
Cardiac Sarcoidosis
Sarcoidosis is a systemic disease of unknown origin characterized by the infiltration of non-necrotizing granulomas that can affect any organ. The presentation of cardiac involvement can range fromExpand
Sarcoid Heart Disease: A Case Report and Literature Review
Sarcoid Heart Disease (SHD), often misdiagnosed as tuberculosis is a potentially life-threatening condition. Cardiac manifestation of sarcoidosis is a challenging clinical condition as it isExpand
Effect of Corticosteroid Therapy in Patients with Cardiac Sarcoidosis on Frequency of Venous Thromboembolism.
TLDR
Contrary to previous studies, this current study found that neither sarcoidosis nor CS is an independent risk factor for VTE and corticosteroid therapy was associated with an increased risk of VTE. Expand
Case Report: TNFα Antagonists Are an Effective Therapy in Cardiac Sarcoidosis
TLDR
TNFα antagonists were effective in refractory and/or relapsing CS treated by corticosteroids and/ or immunosuppressive agents, without serious adverse events, and should be considered earlier in CS treatment scheme. Expand
Host-microbe interactions in the pathogenesis and clinical course of sarcoidosis
TLDR
The scientific evidence on the interaction of microbes with immune cells that may be implicated in the immunopathogenesis of sarcoidosis is discussed, and recent studies exploring potential implications of human microbiota in the pathogenesis and the clinical course are highlighted. Expand
Arrhythmogenic Left Ventricular Cardiomyopathy: Genotype-Phenotype Correlations and New Diagnostic Criteria
TLDR
An overview of the current knowledge on the genetic basis, the phenotypic expressions, and the diagnosis of left-sided variants, both biventricular and left-dominant, of ACM is offered. Expand
Inpatient Prevalence, Expenditures, and Comorbidities of Sarcoidosis: Nationwide Inpatient Sample 2013–2014
TLDR
Analysis of comorbidities found that patients with sarcoidosis had significantly higher odds of atrial fibrillation and a higher risk of several cardiac comorbridities than propensity-matched patients without sarcoideosis. Expand

References

SHOWING 1-10 OF 142 REFERENCES
Cardiac sarcoidosis-state of the art review.
TLDR
The evidence to support a role for cardiac magnetic resonance imaging in the initial evaluation of selected patients with suspected cardiac sarcoidosis is reviewed, with cardiac positron emission tomography (PET) as an alternative or complementary initial diagnostic test in a subgroup of patients in whom CMR may be contra-indicated or when CMR is negative with continued clinical concern for myocardial inflammation. Expand
Cardiac involvement in sarcoidosis: evolving concepts in diagnosis and treatment.
TLDR
The prognosis of cardiac sarCOidosis is variable, but mortality rates of untreated cardiac sarcoidosis are high, and corticosteroids remain the mainstay of treatment. Expand
Multimodality imaging in the diagnosis and management of cardiac sarcoidosis
TLDR
Diagnosing CS via myocardial biopsy is unreliable due to the characteristic skip lesions of CS and sampling error, and multiple studies have evaluated the use of FDGPET and Cardiac Magnetic Resonance in diagnosing CS and predicting adverse outcomes. Expand
Coronary Sarcoidosis Presenting as Acute Coronary Syndrome
TLDR
A case of epicardial coronary involvement by sarcoidosis is described, where the diagnosis was made by surgical biopsy of the coronary artery in an African American man presenting with acute coronary syndrome and recurrent symptomatic restenosis following coronary intervention. Expand
Improved detection of cardiac sarcoidosis using magnetic resonance with myocardial T2 mapping.
TLDR
A retrospective study of 50 consecutive subjects with histologically proven sarcoidosis who had undergone CMR for suspected CS between 2010 and 2013, showing that CMR with T2 mapping improves the detection of active myocarditis compared with LGE alone and provides complementary myocardial characterization relative to LGE. Expand
A concise review of pulmonary sarcoidosis.
TLDR
There is increasing evidence to support that one or more infectious agents may cause sarcoidosis, although this organism may no longer be viable in the patient, and new and more potent antiinflammatory agents have been developed. Expand
Prevalence of cardiac sarcoidosis in white population: a case–control study
TLDR
A CS Risk Index was developed using a multivariate model to predict CS, achieving an accuracy of 82%, sensitivity of 50%, specificity of 94%, and likelihood ratio 8.1. Expand
Evaluation of Known or Suspected Cardiac Sarcoidosis
TLDR
The various roles that different imaging modalities provide in the evaluation and management of patients with known or suspected cardiac sarcoidosis are reviewed. Expand
Histologic diagnostic rate of cardiac sarcoidosis: evaluation of endomyocardial biopsies.
TLDR
The diagnostic rate achieved with biopsy in cardiac sarcoidosis is low; the patients with sarcoIDosis and evidence of significant cardiac involvement should be treated for cardiac sarCOidosis despite negative myocardial biopsies for this disease. Expand
Diagnostic value of speckle-tracking echocardiography in confirmed cardiac sarcoidosis
TLDR
Evaluation of global and regional biventricular deformation properties derived from 2D longitudinal strain imaging revealed impairment of longitudinal performance in CS-positive patients as compared to CS-negative individuals and identified the LV global longitudinal strain to have the highest predicted value for the diagnosis of CS. Expand
...
1
2
3
4
5
...