Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction.

@article{Most2006CardiacSP,
  title={Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction.},
  author={P. F. J. van der Most and Hanna Seifert and E. Mei Gao and Hajime Funakoshi and Mirko Voelkers and J{\"o}rg Heierhorst and Andrew Remppis and Sven T Pleger and Brent R Degeorge and Andrea D. Eckhart and Arthur M Feldman and Walter J Koch},
  journal={Circulation},
  year={2006},
  volume={114 12},
  pages={1258-68}
}
BACKGROUND Diminished cardiac S100A1 protein levels are characteristic of ischemic and dilated human cardiomyopathy. Because S100A1 has recently been identified as a Ca2+-dependent inotropic factor in the heart, this study sought to explore the pathophysiological relevance of S100A1 levels in development and progression of postischemic heart failure (HF). METHODS AND RESULTS S100A1-transgenic (STG) and S100A1-knockout (SKO) mice were subjected to myocardial infarction (MI) by surgical left… CONTINUE READING