Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure.

@article{Lunde2012CardiacOS,
  title={Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure.},
  author={Ida G Lunde and Jan M. Aronsen and Heidi Kval{\o}y and Eirik Qvigstad and Ivar Sjaastad and Theis T{\o}nnessen and Geir Christensen and Line M. Gr{\o}nning-Wang and Cathrine Rein Carlson},
  journal={Physiological genomics},
  year={2012},
  volume={44 2},
  pages={
          162-72
        }
}
  • Ida G Lunde, Jan M. Aronsen, +6 authors Cathrine Rein Carlson
  • Published 2012
  • Medicine, Biology
  • Physiological genomics
  • Reversible protein O-GlcNAc modification has emerged as an essential intracellular signaling system in several tissues, including cardiovascular pathophysiology related to diabetes and acute ischemic stress. We tested the hypothesis that cardiac O-GlcNAc signaling is altered in chronic cardiac hypertrophy and failure of different etiologies. Global protein O-GlcNAcylation and the main enzymes regulating O-GlcNAc, O-GlcNAc transferase (OGT), O-GlcNAcase (OGA), and glutamine-fructose-6-phosphate… CONTINUE READING

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