Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure.

  title={Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure.},
  author={Ida Gjervold Lunde and Jan M. Aronsen and Heidi Kval\oy and Eirik Qvigstad and Ivar Sjaastad and Theis T\onnessen and Geir Christensen and Line Mariann Gr\onning-Wang and Cathrine Rein Carlson},
  journal={Physiological genomics},
  volume={44 2},
Reversible protein O-GlcNAc modification has emerged as an essential intracellular signaling system in several tissues, including cardiovascular pathophysiology related to diabetes and acute ischemic stress. We tested the hypothesis that cardiac O-GlcNAc signaling is altered in chronic cardiac hypertrophy and failure of different etiologies. Global protein O-GlcNAcylation and the main enzymes regulating O-GlcNAc, O-GlcNAc transferase (OGT), O-GlcNAcase (OGA), and glutamine-fructose-6-phosphate… CONTINUE READING


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