Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues

@inproceedings{Ravenscroft2016CardiacNC,
  title={Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues},
  author={Stephanie M. Ravenscroft and Amy V. Pointon and Awel W. Williams and Michael J Cross and James E. Sidaway},
  booktitle={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2016}
}
The immature phenotype of stem cell derived cardiomyocytes is a significant barrier to their use in translational medicine and pre-clinical in vitro drug toxicity and pharmacological analysis. Here we have assessed the contribution of non-myocyte cells on the contractile function of co-cultured human embryonic stem cell derived cardiomyocytes (hESC-CMs) in spheroid microtissue format. Microtissues were formed using a scaffold free 96-well cell suspension method from hESC-CM cultured alone (CM… CONTINUE READING

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