Cardiac Nitric Oxide Synthases and Na⁺/K⁺-ATPase in the Rat Model of Polycystic Ovary Syndrome Induced by Dihydrotestosterone.

@article{Tepavevi2015CardiacNO,
  title={Cardiac Nitric Oxide Synthases and Na⁺/K⁺-ATPase in the Rat Model of Polycystic Ovary Syndrome Induced by Dihydrotestosterone.},
  author={S. Tepav{\vc}evi{\'c} and D. V. Milutinovi{\'c} and D. Macut and J. Stani{\vs}i{\'c} and M. Nikolic and I. Bo{\vz}i{\'c}-Anti{\'c} and S. Rodaljevi{\'c} and J. Bjekic-Macut and G. Mati{\'c} and G. Kori{\'c}anac},
  journal={Experimental and clinical endocrinology \& diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association},
  year={2015},
  volume={123 5},
  pages={
          303-7
        }
}
Nitric oxide synthases (NOSs) and Na(+)/K(+)-ATPase are enzymes essential for regular functioning of the heart. Since both enzymes are under insulin and androgen regulation and since insulin action and androgen level were disturbed in polycystic ovary syndrome (PCOS), we hypothesized that cardiac nitric oxide (NO) production and sodium/potassium transport would be deteriorated in PCOS. To test our hypothesis we introduced animal model of PCOS based on dihydrotestosterone (DHT) treatment of… Expand

References

SHOWING 1-10 OF 41 REFERENCES
Dihydrotestosterone deteriorates cardiac insulin signaling and glucose transport in the rat model of polycystic ovary syndrome
Cardiac nitric oxide synthases are elevated in dietary copper deficiency.
Induction of calcium-dependent nitric oxide synthases by sex hormones.
Does oestradiol attenuate the damaging effects of a fructose-rich diet on cardiac Akt/endothelial nitric oxide synthase signalling?
Analysis of the vascular responses in a murine model of polycystic ovary syndrome.
Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart
The mechanisms involved in the action of metformin in regulating ovarian function in hyperandrogenized mice.
A supraphysiological dose of testosterone induces nitric oxide production and oxidative stress
...
1
2
3
4
5
...