Cardiac Mechano-Electric Coupling: Acute Effects of Mechanical Stimulation on Heart Rate and Rhythm.

  title={Cardiac Mechano-Electric Coupling: Acute Effects of Mechanical Stimulation on Heart Rate and Rhythm.},
  author={T. Alexander Quinn and Peter Kohl},
  journal={Physiological reviews},
The heart is vital for biological function in almost all chordates, including human. It beats continually throughout our life, supplying the body with oxygen and nutrients while removing waste products. If it stops - so does life. The heartbeat involves precise coordination of the activity of billions of individual cells, as well as their swift and well-coordinated adaption to changes in physiological demand. Much of the vital control of cardiac function occurs at the level of individual… 
Modelling the cardiac response to a mechanical stimulation using a low-order model of the heart.
It is demonstrated that the mechano-electric feedback plays a crucial role in mechanical generation and recovery from arrhythmia which has been observed in experimental studies and an optimal value of the impulse amplitude is found above or below which the impulse maximises the stabilisation.
Sinoatrial Node Structure, Mechanics, Electrophysiology and the Chronotropic Response to Stretch in Rabbit and Mouse
The results suggest that structural, mechanical, and background electrophysiological properties of the SAN influence the chronotropic response to stretch, and that pharmacological modification to prolong mouse SAN action potential plateau duration rectified the direction of BR changes during sustained stretch.
Active force generation contributes to the complexity of spontaneous activity and to the response to stretch of murine cardiomyocyte cultures
The notion that in a spontaneously firing network of cardiomyocytes, active force generation, rather than stretch‐activated channels, is involved mechanistically in the complexity of the spatiotemporal patterns of spontaneous activity and in the stretch‐induced acceleration of beating is supported.
TRPA1 is a source of calcium-mediated cardiac mechano-arrhythmogenesis
The results demonstrate that TRPA1 channels act as a trigger for stretch-induced excitation and create a substrate for complex arrhythmic activity (via Ca2+-overload) and thus may represent a novel anti-arrhythmmic target in cardiac diseases in which TRPA 1 channel expression and activity are augmented.
Drivers of Sinoatrial Node Automaticity in Zebrafish: Comparison With Mechanisms of Mammalian Pacemaker Function
It is demonstrated that the principal components of the coupled membrane- Ca2+ pacemaker system that drives automaticity in mammals are also active in the zebrafish, and that the effects of extra- and intracardiac control of heart rate seen in mammal are also present.
What keeps us ticking? Sinoatrial node mechano-sensitivity: the grandfather clock of cardiac rhythm
The rhythmic and spontaneously generated electrical excitation that triggers the heartbeat originates in the sinoatrial node (SAN). SAN automaticity has been thoroughly investigated, which has
Mechano-arrhythmogenicity is enhanced during late repolarisation in ischemia and driven by a TRPA1-, calcium-, and reactive oxygen species-dependent mechanism
In ischemia, mechano-arrhythmogenicity is enhanced specifically during the VP and is mediated by ROS, TRPA1, and Ca2+.
Mechanical stimulation of endocardial Purkinje fibres can trigger ventricular arrhythmias
Observations in rat and sheep hearts are interpreted as evidence for a role of PFs in the generation of some mechanically-induced arrhythmia.
Passive myocardial mechanical properties: meaning, measurement, models
This review defines important concepts useful for characterising passive mechanical tissue properties, and compares a variety of in vitro and in vivo techniques that allow one to assess tissue mechanics, and provides insight into determinants of myocardial stiffness in situ.


Cardiac mechano-electric coupling: a role in regulating normal function of the heart?
  • T. Quinn
  • Medicine
    Cardiovascular research
  • 2015
MEC is understood to be important in numerous cardiac diseases, for instance contributing to the electrophysiological effects of non-uniform contraction, the reduced arrhythmia threshold accompanying atrial or ventricular enlargement, and the impact of pulmonary vein loading on atrial fibrillation.
Mechano-Electric Feedback in the Heart: Effects on Heart Rate and Rhythm
This chapter will review MEF effects on heart rate and rhythm, distinguishing between pro- and anti-arrhythmic effects, and elucidate the extent to which stretch-activated ion channels (SAC) may explain observed responses.
Stretch-induced changes in heart rate and rhythm: clinical observations, experiments and mathematical models.
Rabbit models of cardiac mechano-electric and mechano-mechanical coupling
Cardiac Mechano-Gated Ion Channels and Arrhythmias.
This review focuses on acute mechanical effects on cardiac electrophysiology, explores molecular candidates underlying observed responses, and discusses their pharmaceutical regulation.
The importance of non-uniformities in mechano-electric coupling for ventricular arrhythmias
  • T. Quinn
  • Medicine, Biology
    Journal of Interventional Cardiac Electrophysiology
  • 2013
The present review explores the potential role of mechano-electric coupling in ventricular arrhythmogenesis, with a focus on the importance of non-uniformity in mechanical function for the induction and sustenance of ventricular tachyarrhythmias.
An integrative appraisal of mechano-electric feedback mechanisms in the heart.
Cellular mechanisms of cardiac mechano-electric feedback in a mathematical model.
The model is sufficiently complete to reproduce experimental findings and to help identify causally linked events and may help to explain some of the contradictory data in the literature.
Mechano-electrical feedback in the clinical setting: Current perspectives.