Cardiac MRI: a Translational Imaging Tool for Characterizing Anthracycline-Induced Myocardial Remodeling.

@article{Nguyen2016CardiacMA,
  title={Cardiac MRI: a Translational Imaging Tool for Characterizing Anthracycline-Induced Myocardial Remodeling.},
  author={Kim-Lien Nguyen and Peng Hu and Daniel B. Ennis and Jiaxin Shao and Kimberly A Pham and Joseph J. Chen},
  journal={Current oncology reports},
  year={2016},
  volume={18 8},
  pages={
          48
        }
}
Cardiovascular side effects of cancer therapeutics are the leading causes of morbidity and mortality in cancer survivors. Anthracyclines (AC) serve as the backbone of many anti-cancer treatment strategies, but dose-dependent myocardial injury limits their use. Cumulative AC exposure can disrupt the dynamic equilibrium of the myocardial microarchitecture while repeated injury and repair leads to myocyte loss, interstitial myocardial fibrosis, and impaired contractility. Although children are… CONTINUE READING