Cardiac Lineage Protein-1 (CLP-1) Regulates Cardiac Remodeling via Transcriptional Modulation of Diverse Hypertrophic and Fibrotic Responses and Angiotensin II-transforming Growth Factor β (TGF-β1) Signaling Axis*

@article{Mascareno2012CardiacLP,
  title={Cardiac Lineage Protein-1 (CLP-1) Regulates Cardiac Remodeling via Transcriptional Modulation of Diverse Hypertrophic and Fibrotic Responses and Angiotensin II-transforming Growth Factor $\beta$ (TGF-$\beta$1) Signaling Axis*},
  author={Eduardo Mascareno and Josephine Galatioto and Inna Rozenberg and Louis Salciccioli and Haroon Kamran and Jason M Lazar and Fang Liu and Thierry Pedrazzini and M. A. Q. Siddiqui},
  journal={The Journal of Biological Chemistry},
  year={2012},
  volume={287},
  pages={13084 - 13093}
}
Background: CLP-1 heterozygous mice exhibit enhanced susceptibility to cardiac stress. Results: Angiotensin-II-induced left ventricular hypertrophy and fibrosis were enhanced, and the Smad3 and Stat3 signaling was stimulated in CLP-1+/− mice. Conclusion: CLP-1 controls the hypertrophy and fibrotic response during cardiac remodeling. Significance: Our results offer the potential of targeting CLP-1 for therapeutic intervention in cardiac disease. It is well known that the renin-angiotensin system… 
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