Cardiac Hypertrophy in Mice with Long-Chain Acyl-CoA Dehydrogenase (LCAD) or Very Long-Chain Acyl-CoA Dehydrogenase (VLCAD) Deficiency

@inproceedings{Cox2009CardiacHI,
  title={Cardiac Hypertrophy in Mice with Long-Chain Acyl-CoA Dehydrogenase (LCAD) or Very Long-Chain Acyl-CoA Dehydrogenase (VLCAD) Deficiency},
  author={Keith B. Cox and Jian-qiang Liu and Liqun Tian and Stephen Barnes and Qinglin Yang and Philip A. Wood},
  booktitle={Laboratory Investigation},
  year={2009}
}
Cardiac hypertrophy is a common finding in human patients with inborn errors of long-chain fatty acid oxidation. Mice with either very long-chain acyl-coenzyme A dehydrogenase deficiency (VLCAD–/–) or long-chain acyl-coenzyme A dehydrogenase deficiency (LCAD–/–) develop cardiac hypertrophy. Cardiac hypertrophy, initially measured using heart/body weight ratios, was manifested most severely in LCAD–/– male mice. VLCAD–/– mice, as a group, showed a mild increase in normalized cardiac mass (8.8… CONTINUE READING

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Very LongChain Acyl-Coenzyme A Dehydrogenase Deficiency

N. D. Leslie, B. T. Tinkle
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