• DOI:10.1038/182957A0
• Corpus ID: 4255155

Cardiac Glycosides and Thyroidal Iodide Transport

@article{Wolff1958CardiacGA,
  title={Cardiac Glycosides and Thyroidal Iodide Transport},
  author={John B. Wolff and John R. Maurey},
  journal={Nature},
  year={1958},
  volume={182},
  pages={957-957}
}

• J. Wolff, J. R. Maurey
• Published 4 October 1958
• Biology, Chemistry
• Nature

DURING the past few years, it has become apparent that an important action of the cardiac glycosides involves the transport of potassium ions into the cell. It has also become possible, by the use of potassium-depleted erythrocytes, to test the relative inhibitory potency of such glycosides or their aglycones in vitro1,2. Approximately 80 per cent of the potassium influx can be inhibited by the glycoside by an action that appears to involve competition by drug and potassium ions for the active transport site. The transport of chloride ions in the stomach appears to be similarly affected3. Since the maintenance of a concentration gradient for iodide by an ‘active transport’ is one of the fundamental properties of thyroid tissue, we determined whether or not iodide transport was likewise inhibited by the cardiac glycosides.