Cardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death

  title={Cardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death},
  author={Laurie Menger and Erika Vacchelli and Sandy Adjemian and Isabelle Martins and Yuting Ma and Shensi Shen and Takahiro Yamazaki and Abdul Qader Sukkurwala and Mick{\"a}el Michaud and Gregoire Mignot and Fr{\'e}d{\'e}ric Schlemmer and Eric Sulpice and Clara Locher and Xavier Gidrol and François Ghiringhelli and Nazanine Modjtahedi and Lorenzo Galluzzi and Fabrice Andr{\'e} and Laurence Zitvogel and Oliver Kepp and Guido Kroemer},
  journal={Science Translational Medicine},
  pages={143ra99 - 143ra99}
Cardiac glycosides kill cancer cells in a way that stimulates the immune response. A Cancer Double Feature—3807 A traditional chemotherapeutic drug performs a one-act play: It enters and kills a dividing cancer cell and then takes its bow. However, some chemotherapeutics have a wider range—they not only kill individual cancer cells but also do so in such a way that the dead cells function as a vaccine that primes the immune system to attack other cancer cells. Menger et al. now identify cardiac… 

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