Cardiac Fibroblasts Aggravate Viral Myocarditis: Cell Specific Coxsackievirus B3 Replication

@inproceedings{Lindner2014CardiacFA,
  title={Cardiac Fibroblasts Aggravate Viral Myocarditis: Cell Specific Coxsackievirus B3 Replication},
  author={Diana Lindner and Jia Li and Konstantinos Savvatis and Karin Klingel and Stefan S Blankenberg and Carsten Tsch{\"o}pe and Dirk Westermann},
  booktitle={Mediators of inflammation},
  year={2014}
}
Myocarditis is an inflammatory disease caused by viral infection. Different subpopulations of leukocytes enter the cardiac tissue and lead to severe cardiac inflammation associated with myocyte loss and remodeling. Here, we study possible cell sources for viral replication using three compartments of the heart: fibroblasts, cardiomyocytes, and macrophages. We infected C57BL/6j mice with Coxsackievirus B3 (CVB3) and detected increased gene expression of anti-inflammatory and antiviral cytokines… CONTINUE READING

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