Cardiac Contractility: How Calcium Activates the Myofilaments

@article{Regg1998CardiacCH,
  title={Cardiac Contractility: How Calcium Activates the Myofilaments},
  author={Johann Caspar R{\"u}egg},
  journal={Naturwissenschaften},
  year={1998},
  volume={85},
  pages={575-582}
}
concentrations tropomyosin is located at the edge of the thin filament, thereby interfering with the formation of strong actin-myosin linkages (blocked state). An increase in Ca2+ activity causes an azimuthal shift of tropomyosin around the filament (by about 30°), thereby increasing the probability of low-force crossbridge interaction, a process which by cooperative effects induces further tropomyosin movement (by an additional 10°) which results in the open state of the filament characterized… CONTINUE READING
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