Cardiac Bmi1+ cells contribute to myocardial renewal in the murine adult heart

  title={Cardiac Bmi1+ cells contribute to myocardial renewal in the murine adult heart},
  author={I{\~n}igo Valiente-Alandi and Carmen Albo-Castellanos and Diego Herrero and Elvira Arza and Mar{\'i}a L. Garc{\'i}a-G{\'o}mez and Jos{\'e} C Segovia and Mario R Capecchi and Ant{\'o}nio Bernad},
  booktitle={Stem Cell Research & Therapy},
The mammalian adult heart maintains a continuous, low cardiomyocyte turnover rate throughout life. Although many cardiac stem cell populations have been studied, the natural source for homeostatic repair has not yet been defined. The Polycomb protein BMI1 is the most representative marker of mouse adult stem cell systems. We have evaluated the relevance and role of cardiac Bmi1 + cells in cardiac physiological homeostasis. Bmi1 CreER/+;Rosa26 YFP/+ (Bmi1-YFP) mice were used for lineage tracing… CONTINUE READING
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