Cardiac Arrhythmias Following Intravenous Nicotine: Experimental Study in Dogs

@article{Mehta1997CardiacAF,
  title={Cardiac Arrhythmias Following Intravenous Nicotine: Experimental Study in Dogs},
  author={Mahaveer C Mehta and Abnash C. Jain and Anurag Mehta and Mike Billie},
  journal={Journal of Cardiovascular Pharmacology and Therapeutics},
  year={1997},
  volume={2},
  pages={291 - 297}
}
Background: Nicotine, the active agent in tobacco, is released into the circulation during cigarette smoking. It elevates plasma catecholamines, heart rate, and arterial blood pressure; produces coronary spasm; and increases myocardial work and oxygen demand with con comitant reduction in oxygen supply. This may generate cardiac arrhythmias that might con tribute to an increased incidence of sudden death due to smoking. It is hypothesized that acute administration of nicotine will induce… CONTINUE READING

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