Cardiac Action and Pacemaker Potentials based on the Hodgkin-Huxley Equations

@article{Noble1960CardiacAA,
  title={Cardiac Action and Pacemaker Potentials based on the Hodgkin-Huxley Equations},
  author={Denis Noble},
  journal={Nature},
  year={1960},
  volume={188},
  pages={495-497}
}
  • D. Noble
  • Published 1960
  • Chemistry, Medicine
  • Nature
SINCE the equations describing the nerve action potential were formulated by Hodgkin and Huxley1, the range of phenomena to which they have been shown to apply has been greatly extended. Huxley2has applied them to the influence of temperature on the propagated response and to the repetitive firing observed in low calcium concentrations. More recently, Fitzhugh3 has shown that the long action potentials induced by tetraethylammonium ions in squid nerve may also be reproduced. 
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References

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The effect of the cardiac membrane potential on the rapid availability of the sodium‐carrying system
  • S. Weidmann
  • Chemistry, Medicine
  • The Journal of physiology
  • 1955
TLDR
The present experiments were undertaken in order to look for a similar effect in mammalian Purkinje fibres by means of a feedback circuit the 'resting' potential could be chosen at will; its effect was observed on certain features of the action potential which are thought to be indicative of the sodium permeability, namely the upstroke velocity and the size of the 'overshoot'. Expand
A quantitative description of membrane current and its application to conduction and excitation in nerve
TLDR
This article concludes a series of papers concerned with the flow of electric current through the surface membrane of a giant nerve fibre by putting them into mathematical form and showing that they will account for conduction and excitation in quantitative terms. Expand
Thresholds and Plateaus in the Hodgkin-Huxley Nerve Equations
  • R. FitzHugh
  • Physics, Medicine
  • The Journal of general physiology
  • 1960
TLDR
Since the theoretical membrane conductance curves differ significantly from the experimental ones, further experimental analysis of ionic currents with tetraethylammonium is needed to decide whether the Hodgkin-Huxley model can be generalized to explain these experiments completely. Expand
ION MOVEMENTS DURING NERVE ACTIVITY
  • A. Huxley
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
  • 1959
TLDR
There are several different ways in which the electric activity of a nerve fiber depends on movements of inorganic ions, including in the maintenance of the resting potential, which Bernstein (1902) suggested was a concentration potential. Expand