Cardamonin suppresses melanogenesis by inhibition of Wnt/beta-catenin signaling.

  title={Cardamonin suppresses melanogenesis by inhibition of Wnt/beta-catenin signaling.},
  author={Munju Cho and Minjung Ryu and Yongsu Jeong and Y K Chung and Dong-Eun Kim and Ho-Song Cho and Sangjin Kang and Jong-Sub Han and Min-Youl Chang and Cheon-Koo Lee and Muhyun Jin and Ho-Jeoung Kim and Sangtaek Oh},
  journal={Biochemical and biophysical research communications},
  volume={390 3},
Wnt/beta-catenin signaling plays important roles in many developmental processes, including neural crest-derived melanocyte development. Here we show that cardamonin, a calchone from Aplinia katsumadai Hayata, inhibited pigmentation in melanocytes through suppression of Wnt/beta-catenin signaling pathway. Cardamonin significantly suppressed the expression of microphthalmia-associated transcription factor (MITF) and tyrosinase, which are melanocyte differentiation-associated markers, in human… CONTINUE READING
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