Carcinoma of the extrahepatic bile ducts. Histologic types, stage of disease, grade, and survival rates

  title={Carcinoma of the extrahepatic bile ducts. Histologic types, stage of disease, grade, and survival rates},
  author={Donald E. Henson and Jorge Albores–Saavedra and Donald K. Corle},
Data on patients with extrahepatic bile duct carcinomas recorded in the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute were reviewed, We analyzed the records of 1766 patients reported during a 10‐year period (1977–1986). These tumors occurred primarily in older age groups and were slightly more common in males. Histologic grade, histologic types, and stage of disease are useful prognostic indicators. The 5‐year survival rate for patients with Stage I… 

Carcinoma of the Extrahepatic Bile Ducts

This analysis is based primarily on published reports on the prognostic factors in cancers of the extrahepatic bile ducts, including data from the Surveil­lance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute.

Invasive Papillary Carcinomas of the Extrahepatic Bile Ducts: a Clinicopathologic and Immunohistochemical Study of 13 Cases

There is no correlation between p53, Ki-67, and Dpc4 expression in these tumors and survival of the patients, and the histologic type and the stage of the disease are the most important prognostic factors in these papillary carcinomas.

Extrahepatic Biliary Tract and the Ampulla of Vater Cancers

This chapter reviews the most useful prognostic factors that are available for carcinomas arising in the gallbladder, extrahepatic bile ducts, or the ampulla of Vater, and concludes that the single most important factor having the greatest effect on survival is the extent of tumor at the time of diagnosis.

Prognostic Significance of Proliferative Cell Nuclear Antigen in Carcinoma of the Extrahepatic Bile Duct

A retrospective study with the medical records of 44 consecutive patients who underwent surgery for histologically extrahepatic bile duct cancer (stage 3 or 4) at Osaka Police Hospital suggested that proliferative activity influenced the postoperative prognosis of extrahePatic biles duct cancer.

Update on the Management of Cholangiocarcinoma

Several novel interventional and endoscopic techniques for the diagnosis and management of non-operable CC have been developed: initial results show improvements in symptoms and progression-free survival, but further randomised studies are required to establish their role in the management of CC.

Minimally invasive papillary carcinoma of the extrahepatic bile ducts.

A case of papillary carcinoma of the common bile duct showing minimal invasion is reported, and separation of invasive from non-invasive or minimally invasive papillary cancers is critical in estimating the patient outcome.

Cholangiocarcinoma: From Mechanisms to Management

This chapter concludes with a discussion of ongoing and future research in cholangiocarcinoma, a rare malignancy with recognized risk factors and a very poor prognosis with many patients having advanced disease at presentation.

Clinicopathological review of 61 patients with early bile duct cancer.

  • J. ChaM. Kim S. Jang
  • Medicine
    Clinical oncology (Royal College of Radiologists (Great Britain))
  • 2006



Adenocarcinoma of the extrahepatic biliary tree.

Increasing survival rates for carcinoma of the biliary tree could reflect the selection of patients for referral to a specialist centre as well as modern improvements in diagnosis and treatment. To

Evolution of carcinoma in the extrahepatic bile ducts

The histopathology of 43 cases of carcinoma in the extrahepatic bile ducts was reported, and it is likely that early cancers were usually polypoid or papillary in gross shape and that most carcinomas arose from a pre‐existing adenoma.

Squamous cell carcinoma of the proximal bile duct — A case report

A 56‐year‐old white male with abdominal pain, vomiting, and jaundice was found on exploration to have squamous cell carcinoma of the hepatic ducts with metastasis to the liver, but his postoperative course was of progressive liver failure, which necessitated cessation of radiation therapy.

Biliary tract carcinoma associated with ulcerative colitis.

This paper reports 15 well-documented cases in which a biliary tract tumour has developed in a patient with ulcerative colitis, suggesting that these tumours are approximately 10 times more frequent in patients with ulcers than in the general population.

Bile duct carcinoma and biliary tract dysplasia in chronic ulcerative colitis.

The development of primary sclerosing cholangitis in the biliary tract of patients with ulcerative colitis appears to precede dysplasia and may be a marker of patients at risk for developing biliary tracts carcinomas.

Carcinoma of the biliary tract complicating chronic ulcerative colitis

Reports of the frequent occurrence of biliary tract disease in patients with ulcerative colitis and the association of chronic biliary inflammation with tumors suggest that neoplasia of the biliary tree may represent an additional extracolonic complication of chronic inflammatory bowel disease.

The development and extension of hepatohilar bile duct carcinoma. A three‐dimensional tumor mapping in the intrahepatic biliary tree visualized with the aid of a graphics computer system

As extensive a surgical measure as possible should be taken in designing a strategy against this tumor in an effort to visualize three‐dimensionally the distribution of carcinoma and dysplasia.

Diffuse papillomatosis of the gallbladder.

The first case of diffuse papillomatosis of the gallbladder occurred in a patient with a history of chronic ulcerative colitis and sclerosing cholangitis with secondary biliary cirrhosis, and of further interest was the presence of Paneth cells in the gall Bladder lesion.