Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection.

@article{Ames1973CarcinogensAM,
  title={Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection.},
  author={Bruce N. Ames and W E Durston and E F Yamasaki and F D Lee},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1973},
  volume={70 8},
  pages={2281-5}
}
18 Carcinogens, including aflatoxin B(1), benzo(a)pyrene, acetylaminofluorene, benzidine, and dimethylamino-trans-stilbene, are shown to be activated by liver homogenates to form potent frameshift mutagens. We believe that these carcinogens have in common a ring system sufficiently planar for a stacking interaction with DNA base pairs and a part of the molecule capable of being metabolized to a reactive group: these structural features are discussed in terms of the theory of frameshift… CONTINUE READING
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