Carcinogenicity test of six nitrosamides and a nitrosocyanamide administered orally to rats.

@article{Bulay1979CarcinogenicityTO,
  title={Carcinogenicity test of six nitrosamides and a nitrosocyanamide administered orally to rats.},
  author={O. Bulay and S. Mirvish and H. Garc{\'i}a and A. Pelfrene and B. Gold and M. Eagen},
  journal={Journal of the National Cancer Institute},
  year={1979},
  volume={62 6},
  pages={
          1523-8
        }
}
  • O. Bulay, S. Mirvish, +3 authors M. Eagen
  • Published 1979
  • Biology, Medicine
  • Journal of the National Cancer Institute
  • Six nitrosamides [ethylnitrosourea (ENU), 2-hydroxyethylnitrosourea (HENU), carboxymethylnitrosourea, 1-nitroso-5,6-dihydrouracil (NDHU), 1-nitrosohydantoin, and N-methyl-N-nitrosobenzamide (MNB)] and ethylnitrosocyanamide (ENC) were administered chronically in sodium citrate-buffered drinking water to MRC Wistar rats. ENU induced tumors of the reticuloendothelial system (RES) (50% incidence), mammary glands, and large intestine. NDHU in drinking water produced hepatocellular carcinomas (96… CONTINUE READING
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