Carcinogenicity study of doxefazepam administered in the diet to Sprague-Dawley rats.

@article{Borelli1990CarcinogenicitySO,
  title={Carcinogenicity study of doxefazepam administered in the diet to Sprague-Dawley rats.},
  author={G. Borelli and D. Bertoli and P. Chieco},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1990},
  volume={15 1},
  pages={
          82-92
        }
}
Groups of 50 male and 50 female Sprague-Dawley rats were given food containing sufficient doxefazepam, a benzodiazepine derivative, to ensure intakes of 0, 3, 10, or 30 mg/kg/day. These dosages respectively correspond to 2, 20, and 60 times the mean daily hypnotic dose level of an adult man. Rats were treated for 104 weeks and then euthanized. An extensive autopsy was performed on those animals that died intercurrently and on euthanized animals. The chronic administration of doxefazepam did not… Expand
8 Citations
Genotoxicity and carcinogenicity studies of benzodiazepines.

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