Carcinogenicity studies of sodium nitrite and sodium nitrate in F-344 rats.

@article{Maekawa1982CarcinogenicitySO,
  title={Carcinogenicity studies of sodium nitrite and sodium nitrate in F-344 rats.},
  author={A. Maekawa and T. Ogiu and H. Onodera and K. Furuta and C. Matsuoka and Y. Ohno and S. Odashima},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1982},
  volume={20 1},
  pages={
          25-33
        }
}
  • A. Maekawa, T. Ogiu, +4 authors S. Odashima
  • Published 1982
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
The carcinogenicity of sodium and of sodium nitrate was examined in F-344 rats. Sodium nitrite was administered in the drinking-water for 2 yr at levels of 0.125 or 0.25%. Sodium nitrate was given in the diet at levels 2.5 or 5%. A variety of tumours occurred in all groups including the controls. The only significant difference between treated and control groups in the total number of tumours detected in either of the studies was a significant decrease in tumour incidence in the high-dose… Expand
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