Carcinogenicity of metal compounds: possible role of DNA repair inhibition.

  title={Carcinogenicity of metal compounds: possible role of DNA repair inhibition.},
  author={Andrea Hartwig},
  journal={Toxicology letters},
Compounds of chromium, nickel, cadmium, cobalt and arsenic are well-known carcinogens. However, their mode of action is still not fully understood, since, with the exception of chromium(VI), direct genotoxic effects are rather weak and/or restricted to comparatively high concentrations. However, current evidence suggests that DNA repair systems are very sensitive targets for nickel(II), cadmium(II), cobalt(II) and arsenic(III), leading to a diminished removal of endogenous DNA lesions and of… CONTINUE READING