Carcinogenicity of fibrous glass: pleural response in the rat in relation to fiber dimension.

@article{Stanton1977CarcinogenicityOF,
  title={Carcinogenicity of fibrous glass: pleural response in the rat in relation to fiber dimension.},
  author={Marge F. Stanton and M Laynard and A S Tegeris and Eric Miller and Michael May and Elizabeth Kent},
  journal={Journal of the National Cancer Institute},
  year={1977},
  volume={58 3},
  pages={587-603}
}
Seventeen fibrous glasses of diverse type or dimensional distribution induced different incidences of malignant mesenchymal neoplasms when implanted in the pleurae of female Osborne-Mendel rats for periods of more than 1 year. Neoplastic response correlated well with the dimensional distribution of fibers. Fibers less than or equal to 1.5 mu in diameter and greater than 8 mu in length yielded the highest probability of pleural sarcomas, and probability trends suggested that pleural sarcoma… CONTINUE READING