Carcinogenicity of acrylamide in B6C3F(1) mice and F344/N rats from a 2-year drinking water exposure.

  title={Carcinogenicity of acrylamide in B6C3F(1) mice and F344/N rats from a 2-year drinking water exposure.},
  author={Frederick A Beland and Paul W Mellick and Greg R. Olson and Mar{\'i}a Bibiana Mendoza and M. Matilde Marques and Daniel R. Doerge},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
Acrylamide is a component of roasted coffee and certain baked and fried carbohydrate-rich foods prepared at high temperatures. We have assessed the carcinogenicity of acrylamide in male and female B6C3F(1) mice and F344/N rats administered 0, 0.0875, 0.175, 0.35, or 0.70mM acrylamide in the drinking water ad libitum for 2 years. Acrylamide caused significant dose-related decreasing trends in the body weights of F344/N rats. Acrylamide administration resulted in significant dose-related… CONTINUE READING
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