Carcinogenicity bioassays of bromoacetaldehyde and bromoethanol--potential metabolites of dibromoethane.

@article{Duuren1985CarcinogenicityBO,
  title={Carcinogenicity bioassays of bromoacetaldehyde and bromoethanol--potential metabolites of dibromoethane.},
  author={B. L. Van Duuren and I M Seidman and S M Melchionne and Stanley A. Kline},
  journal={Teratogenesis, carcinogenesis, and mutagenesis},
  year={1985},
  volume={5 6},
  pages={393-403}
}
1,2-Dibromoethane (DBE) and two of its potential metabolites, bromoethanol (BE) and bromoacetaldehyde (BA), were tested for carcinogenicity in male and female B6C3F1 mice using 30 animals of each sex per group. The carcinogen DBE was included in this assay as a positive control. The compounds were administered in distilled drinking water using equimolar concentrations, 4 mmol, of the chemicals. The dose chosen was based on subchronic bioassays of three months' duration. The chronic tests were… CONTINUE READING